Synthesis of (−)−deoxypodophyllotoxin and (−)−epipodophyllotoxin via a multi-enzyme cascade in E. coli

BACKGROUND: The aryltetralin lignan (−)−podophyllotoxin is a potent antiviral and anti-neoplastic compound that is mainly found in Podophyllum plant species. Over the years, the commercial demand for this compound rose notably because of the high clinical importance of its semi-synthetic chemotherap...

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Detalles Bibliográficos
Autores principales: Decembrino, Davide, Raffaele, Alessandra, Knöfel, Ronja, Girhard, Marco, Urlacher, Vlada B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454061/
https://www.ncbi.nlm.nih.gov/pubmed/34544406
http://dx.doi.org/10.1186/s12934-021-01673-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454061/
https://www.ncbi.nlm.nih.gov/pubmed/34544406
http://dx.doi.org/10.1186/s12934-021-01673-5

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