Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice

Somatic mutations in spliceosome genes are found in ~50% of patients with myelodysplastic syndromes (MDS), a myeloid malignancy associated with low blood counts. Expression of the mutant splicing factor U2AF1(S34F) alters hematopoiesis and mRNA splicing in mice. Our understanding of the functionally...

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Detalles Bibliográficos
Autores principales: Kim, Sanghyun P., Srivatsan, Sridhar N., Chavez, Monique, Shirai, Cara L., White, Brian S., Ahmed, Tanzir, Alberti, Michael O., Shao, Jin, Nunley, Ryan, White, Lynn S., Bednarski, Jeff, Pehrson, John R., Walter, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454217/
https://www.ncbi.nlm.nih.gov/pubmed/34469727
http://dx.doi.org/10.1016/j.celrep.2021.109626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454217/
https://www.ncbi.nlm.nih.gov/pubmed/34469727
http://dx.doi.org/10.1016/j.celrep.2021.109626

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