Cargando…

Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling

Nicotine is the principal alkaloid of tobacco often manufactured into cigarettes and belongs to a highly addictive class of drugs. Nicotine attenuates the neuroinflammation induced by microglial activation. However, the molecular target(s) underlying anti-inflammatory action of nicotine has not been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hongyuan, Peng, Yinghua, Lin, Cong, Zhang, Xiaozheng, Zhang, Tianshu, Wang, Yibo, Li, Yuanpeng, Wu, Siru, Wang, Hongshuang, Hutchinson, Mark R., Watkins, Linda R., Wang, Xiaohui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454564/ https://www.ncbi.nlm.nih.gov/pubmed/34557761 http://dx.doi.org/10.1016/j.xinn.2021.100111

Ejemplares similares

Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2
por: Wu, Siru, et al.
Publicado: (2022)

Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia
por: Wang, Xue, et al.
Publicado: (2022)

ACT001 Inhibits TLR4 Signaling by Targeting Co-Receptor MD2 and Attenuates Neuropathic Pain
por: Zhang, Tianshu, et al.
Publicado: (2022)

The Associations of Trans-3′-Hydroxy Cotinine, Cotinine, and the Nicotine Metabolite Ratio in Pediatric Patients with Tobacco Smoke Exposure
por: Mahabee-Gittens, E. Melinda, et al.
Publicado: (2023)

Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions
por: Tan, Xiaoying, et al.
Publicado: (2021)

Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease
por: Barreto, George E., et al.
Publicado: (2015)

A comparison of nicotine dose estimates in smokers between filter analysis, salivary cotinine, and urinary excretion of nicotine metabolites
por: St.Charles, F. K., et al.
Publicado: (2006)

Targeting trimeric transmembrane domain 5 of oncogenic latent membrane protein 1 using a computationally designed peptide
por: Wang, Yibo, et al.
Publicado: (2019)

Physiologically Based Pharmacokinetic Modelling for Nicotine and Cotinine Clearance in Pregnant Women
por: Amice, Basile, et al.
Publicado: (2021)

Nicotine and cotinine in oral fluid: Passive exposure vs active smoking
por: Feng, Sheng, et al.
Publicado: (2018)

Application of Ionic Liquids as Mobile Phase Additives for Simultaneous Analysis of Nicotine and Its Metabolite Cotinine in Human Plasma by HPLC–DAD
por: Axente, Roxana E., et al.
Publicado: (2023)

The pharmacology and therapeutic role of cannabidiol in diabetes
por: Zhang, Jin, et al.
Publicado: (2023)

Immunochromatographic Assessment of Salivary Cotinine and Its Correlation With Nicotine Dependence in Tobacco Chewers
por: Asha, V, et al.
Publicado: (2015)

Saliva cotinine concentrations in pregnant women who smoke and use nicotine patches
por: Claire, Ravinder, et al.
Publicado: (2019)

Urinary Cotinine and Nicotine Dependence Levels in Regular Male Electronic Cigarette Users
por: Pamungkasningsih, Sri Wening, et al.
Publicado: (2021)

Methoxsalen inhibited the acquisition of nicotine self-administration: attenuation by cotinine replacement in rats
por: Ding, Zheng-Ming, et al.
Publicado: (2023)

Biomonitoring of Urinary Cotinine Concentrations Associated with Plasma Levels of Nicotine Metabolites after Daily Cigarette Smoking in a Male Japanese Population
por: Nagano, Taku, et al.
Publicado: (2010)

Comparison of Cotinine Levels in Pregnant Women While Smoking and When Using Nicotine Replacement Therapy
por: Bowker, Katharine A., et al.
Publicado: (2014)

Quantification of Nicotine and Cotinine in Plasma, Saliva, and Urine by HPLC Method in Chewing Tobacco Users
por: Shaik, Fareeda Begum, et al.
Publicado: (2019)

Comparative evaluation of the efficacy of nicotine chewing gum and nicotine patches as nicotine replacement therapy using salivary cotinine levels as a biochemical validation measure
por: Sivasankari, T, et al.
Publicado: (2023)

Possible role of nicotine and cotinine on nitroxidative stress and antioxidant content in saliva of smokeless tobacco consumers
por: Begum, Shaik Fareeda, et al.
Publicado: (2018)

Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling
por: Oliveros-Matus, Patricia, et al.
Publicado: (2020)

In vitro and in vivo application of anti-cotinine antibody and cotinine-conjugated compounds
por: Kim, Hyori, et al.
Publicado: (2014)

Nicotine and Cotinine Induce Neutrophil Extracellular Trap Formation—Potential Risk for Impaired Wound Healing in Smokers
por: Aspera-Werz, Romina H., et al.
Publicado: (2022)

Cotinine inhibits TLR4/NF-κB signaling pathway and improves deep vein thrombosis in rats
por: Cheng, Zhiyuan, et al.
Publicado: (2020)

Utility and Cutoff Value of Hair Nicotine as a Biomarker of Long-Term Tobacco Smoke Exposure, Compared to Salivary Cotinine
por: Kim, Sungroul, et al.
Publicado: (2014)

The Impact of Sex on Changes in Plasma Corticosterone and Cotinine Levels Induced by Nicotine in C57BL/6J Mice
por: Nguyen, Khoa, et al.
Publicado: (2020)

Nicotine and Cotinine Inhibit Catalase and Glutathione Reductase Activity Contributing to the Impaired Osteogenesis of SCP-1 Cells Exposed to Cigarette Smoke
por: Aspera-Werz, Romina H., et al.
Publicado: (2018)

Interrelations of Level of Urinary Cotinine and Score for Fagerstrom Test for Nicotine Dependence among Beedi Smokers, and Smokeless Tobacco Users in India
por: Vinoth Kumar, Nalini M., et al.
Publicado: (2017)

Early-life nicotine or cotinine exposure produces long-lasting sleep alterations and downregulation of hippocampal corticosteroid receptors in adult mice
por: Bastianini, Stefano, et al.
Publicado: (2021)

Association of Maternal Smoking With Child Cotinine Levels
por: Stiby, Alexander I., et al.
Publicado: (2013)

Inefficient TLR4/MD-2 Heterotetramerization by Monophosphoryl Lipid A
por: Casella, Carolyn R., et al.
Publicado: (2013)

Application of HPLC-QQQ-MS/MS and New RP-HPLC-DAD System Utilizing the Chaotropic Effect for Determination of Nicotine and Its Major Metabolites Cotinine, and trans-3′-Hydroxycotinine in Human Plasma Samples
por: Baj, Jacek, et al.
Publicado: (2022)

Microbial-Related Metabolites May Be Involved in Eight Major Biological Processes and Represent Potential Diagnostic Markers in Gastric Cancer
por: Nie, Siru, et al.
Publicado: (2023)

Cotinine analytical workshop report: consideration of analytical methods for determining cotinine in human body fluids as a measure of passive exposure to tobacco smoke.
por: Watts, R R, et al.
Publicado: (1990)

Cotinine-conjugated aptamer/anti-cotinine antibody complexes as a novel affinity unit for use in biological assays
por: Park, Sunyoung, et al.
Publicado: (2012)

Comparison of saliva cotinine and exhaled carbon monoxide concentrations when smoking and after being offered dual nicotine replacement therapy in pregnancy
por: Slaich, Bhavandeep, et al.
Publicado: (2021)

Combined Analysis of the Tobacco Metabolites Cotinine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in Human Urine
por: Kotandeniya, Delshanee, et al.
Publicado: (2014)

Impact of Genetic Variants in the Nicotine Metabolism Pathway on Nicotine Metabolite Levels in Smokers
por: Perez-Paramo, Yadira X., et al.
Publicado: (2023)

Disruption of retinal pigment epithelial cell properties under the exposure of cotinine
por: Zhang, Xiao-Yu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dgvoe9i683vgd5hc7ikctqjnus