Optimisation of a TALE nuclease targeting the HIV co-receptor CCR5 for clinical application

Disruption of the C-C-Chemokine-receptor-5 (CCR5) gene induces resistance towards CCR5-tropic HIV. Here we optimised our previously described CCR5-Uco-TALEN and its delivery by mRNA electroporation. The novel variant, CCR5-Uco-hetTALEN features an obligatory heterodimeric Fok1-cleavage domain, which...

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Detalles Bibliográficos
Autores principales: Schwarze, Lea Isabell, Głów, Dawid, Sonntag, Tanja, Uhde, Almut, Fehse, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455333/
https://www.ncbi.nlm.nih.gov/pubmed/34112993
http://dx.doi.org/10.1038/s41434-021-00271-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455333/
https://www.ncbi.nlm.nih.gov/pubmed/34112993
http://dx.doi.org/10.1038/s41434-021-00271-9

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