CD47-targeting antibodies as a novel therapeutic strategy in hematologic malignancies

CD47 is a surface glycoprotein expressed by host cells to impede phagocytosis upon binding to macrophage SIRPα, thereby represents an immune checkpoint known as the “don't-eat-me” signal. However, accumulating evidence shows that solid and hematologic tumor cells overexpress CD47 to escape immu...

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Detalles Bibliográficos
Autores principales: Sun, Jennifer, Chen, Yixuan, Lubben, Berit, Adebayo, Ola, Muz, Barbara, Azab, Abdel Kareem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455363/
https://www.ncbi.nlm.nih.gov/pubmed/34584838
http://dx.doi.org/10.1016/j.lrr.2021.100268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455363/
https://www.ncbi.nlm.nih.gov/pubmed/34584838
http://dx.doi.org/10.1016/j.lrr.2021.100268

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