MicroRNA-detargeting proves more effective than leader gene deletion for improving safety of oncolytic Mengovirus in a nude mouse model

A dual microRNA-detargeted oncolytic Mengovirus, vMC(24)NC, proved highly effective against a murine plasmacytoma in an immunocompetent syngeneic mouse model; however, there remains the concern of escape mutant development and the potential for toxicity in severely immunocompromised cancer patients...

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Detalles Bibliográficos
Autores principales: Suryawanshi, Yogesh R., Nace, Rebecca A., Russell, Stephen J., Schulze, Autumn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455367/
https://www.ncbi.nlm.nih.gov/pubmed/34589580
http://dx.doi.org/10.1016/j.omto.2021.08.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455367/
https://www.ncbi.nlm.nih.gov/pubmed/34589580
http://dx.doi.org/10.1016/j.omto.2021.08.011

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