Development of a hydroxamamide-based bifunctional chelating agent to prepare technetium-99m-labeled bivalent ligand probes

Hydroxamamide (Ham) is a thiol-free chelating agent that forms technetium-99m ((99m)Tc)-complexes with a metal-to-ligand ratio of 1:2 under moderate reaction conditions. Therefore, Ham-based chelating agents will produce (99m)Tc-labeled compounds with a bivalent targeting scaffold. For their univers...

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Detalles Bibliográficos
Autores principales: Shimizu, Yoichi, Ando, Masato, Iikuni, Shimpei, Watanabe, Hiroyuki, Ono, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455562/
https://www.ncbi.nlm.nih.gov/pubmed/34548586
http://dx.doi.org/10.1038/s41598-021-98235-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455562/
https://www.ncbi.nlm.nih.gov/pubmed/34548586
http://dx.doi.org/10.1038/s41598-021-98235-x

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