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Development of a hydroxamamide-based bifunctional chelating agent to prepare technetium-99m-labeled bivalent ligand probes
Hydroxamamide (Ham) is a thiol-free chelating agent that forms technetium-99m ((99m)Tc)-complexes with a metal-to-ligand ratio of 1:2 under moderate reaction conditions. Therefore, Ham-based chelating agents will produce (99m)Tc-labeled compounds with a bivalent targeting scaffold. For their univers...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455562/ https://www.ncbi.nlm.nih.gov/pubmed/34548586 http://dx.doi.org/10.1038/s41598-021-98235-x |