Epistasis shapes the fitness landscape of an allosteric specificity switch

Epistasis is a major determinant in the emergence of novel protein function. In allosteric proteins, direct interactions between inducer-binding mutations propagate through the allosteric network, manifesting as epistasis at the level of biological function. Elucidating this relationship between loc...

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Detalles Bibliográficos
Autores principales: Nishikawa, Kyle K., Hoppe, Nicholas, Smith, Robert, Bingman, Craig, Raman, Srivatsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455584/
https://www.ncbi.nlm.nih.gov/pubmed/34548494
http://dx.doi.org/10.1038/s41467-021-25826-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455584/
https://www.ncbi.nlm.nih.gov/pubmed/34548494
http://dx.doi.org/10.1038/s41467-021-25826-7

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