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Inhibition of cardiac PERK signaling promotes peripartum cardiac dysfunction

Peripartum cardiomyopathy (PPCM) is a life-threatening heart failure occurring in the peripartum period. Although mal-angiogenesis, induced by the 16-kDa N-terminal prolactin fragment (16 K PRL), is involved in the pathogenesis, the effect of full-length prolactin (23 K PRL) is poorly understood. We...

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Detalles Bibliográficos
Autores principales: Shimizu, Takashi, Taguchi, Akashi, Higashijima, Yoshiki, Kanki, Yasuharu, Nakaki, Ryo, Urade, Yoshihiro, Wada, Youichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455649/
https://www.ncbi.nlm.nih.gov/pubmed/34548576
http://dx.doi.org/10.1038/s41598-021-98344-7