Selective degradation of AR-V7 to overcome castration resistance of prostate cancer

Androgen receptor splice variant 7 (AR-V7), a form of ligand-independent and constitutively activating variant of androgen receptor (AR), is considered as the key driver to initiate castration-resistant prostate cancer (CRPC). Because AR-V7 lacks ligand-binding domain, the AR-targeted therapies that...

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Detalles Bibliográficos
Autores principales: Liu, Yuan, Yu, Cuifu, Shao, Zhenlong, Xia, Xiaohong, Hu, Tumei, Kong, Weiyao, He, Xiaoyue, Sun, Wenshuang, Deng, Yuanfei, Liao, Yuning, Huang, Hongbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455663/
https://www.ncbi.nlm.nih.gov/pubmed/34548474
http://dx.doi.org/10.1038/s41419-021-04162-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455663/
https://www.ncbi.nlm.nih.gov/pubmed/34548474
http://dx.doi.org/10.1038/s41419-021-04162-0

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