SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

While dysregulation of RNA splicing has been recognized as an emerging target for cancer therapy, the functional significance of RNA splicing and individual splicing factors in brain tumors is poorly understood. Here, we identify SON as a master regulator that activates PTBP1-mediated oncogenic spli...

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Detalles Bibliográficos
Autores principales: Kim, Jung-Hyun, Jeong, Kyuho, Li, Jianfeng, Murphy, James M., Vukadin, Lana, Stone, Joshua K., Richard, Alexander, Tran, Johnny, Gillespie, G. Yancey, Flemington, Erik K., Sobol, Robert W., Lim, Ssang-Teak Steve, Ahn, Eun-Young Erin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455679/
https://www.ncbi.nlm.nih.gov/pubmed/34548489
http://dx.doi.org/10.1038/s41467-021-25892-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455679/
https://www.ncbi.nlm.nih.gov/pubmed/34548489
http://dx.doi.org/10.1038/s41467-021-25892-x

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