Cargando…

Affinity Proteomics and Deglycoproteomics Uncover Novel EDEM2 Endogenous Substrates and an Integrative ERAD Network

Various pathologies result from disruptions to or stress of endoplasmic reticulum (ER) homeostasis, such as Parkinson's disease and most neurodegenerative illnesses, diabetes, pulmonary fibrosis, viral infections, and cancers. A critical process in maintaining ER homeostasis is the selection of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Munteanu, Cristian V.A., Chirițoiu, Gabriela N., Chirițoiu, Marioara, Ghenea, Simona, Petrescu, Andrei-Jose, Petrescu, Ştefana M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455867/ https://www.ncbi.nlm.nih.gov/pubmed/34332121 http://dx.doi.org/10.1016/j.mcpro.2021.100125

Ejemplares similares

Dataset of human EDEM2 melanoma cells proteomics, affinity proteomics and deglycoproteomics
por: Chirițoiu, Gabriela N., et al.
Publicado: (2021)

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired
por: Chiritoiu, Marioara, et al.
Publicado: (2020)

Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region
por: Marin, Marioara B., et al.
Publicado: (2012)

Targeting EDEM protects against ER stress and improves development and survival in C. elegans
por: Ghenea, Simona, et al.
Publicado: (2022)

EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning
por: Manica, Georgiana, et al.
Publicado: (2021)

Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition
por: Munteanu, Cristian V. A., et al.
Publicado: (2023)

EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway
por: (Flintoaca) Alexandru, Petruta R., et al.
Publicado: (2023)

Methionine oxidation selectively enhances T cell reactivity against a melanoma antigen
por: Chiriţoiu, Gabriela N., et al.
Publicado: (2023)

C-Terminus Glycans with Critical Functional Role in the Maturation of Secretory Glycoproteins
por: Cioaca, Daniela, et al.
Publicado: (2011)

Mannosidase activity of EDEM1 and EDEM2 depends on an unfolded state of their glycoprotein substrates
por: Shenkman, Marina, et al.
Publicado: (2018)

Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
por: Sokołowska, Iwona, et al.
Publicado: (2015)

Functionalized Graphene Oxide Thin Films for Anti-tumor Drug Delivery to Melanoma Cells
por: Sima, Livia E., et al.
Publicado: (2020)

Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD
por: George, Ginto, et al.
Publicado: (2021)

New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma
por: Militaru, Ioana V., et al.
Publicado: (2023)

Bypass of glycan-dependent glycoprotein delivery to ERAD by up-regulated EDEM1
por: Ron, Efrat, et al.
Publicado: (2011)

Activation of ERAD Pathway by Human Hepatitis B Virus Modulates Viral and Subviral Particle Production
por: Lazar, Catalin, et al.
Publicado: (2012)

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step
por: Ninagawa, Satoshi, et al.
Publicado: (2014)

Therapeutic potential of interleukin-15 in cancer (Review)
por: Isvoranu, Gheorghita, et al.
Publicado: (2021)

Editorial: Unconventional protein secretion: From basic mechanisms to dysregulation in disease
por: Chiritoiu-Butnaru, Marioara, et al.
Publicado: (2022)

Unconventional secretion of FABP4 by endosomes and secretory lysosomes
por: Villeneuve, Julien, et al.
Publicado: (2018)

NPC1 plays a role in the trafficking of specific cargo to melanosomes
por: Rus, Alina Adriana, et al.
Publicado: (2023)

EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD
por: George, Ginto, et al.
Publicado: (2020)

Comparison of Cohesive Models in EDEM and LIGGGHTS for Simulating Powder Compaction
por: Ramírez-Aragón, Cristina, et al.
Publicado: (2018)

Identification of EGF Receptor and Thrombospondin-1 as Endogenous Targets of ER-Associated Degradation Enhancer EDEM1 in HeLa Cells
por: Miura, Kohta, et al.
Publicado: (2023)

Sialocyst of the Parotid Gland in a Child
por: MUNTEANU, MC, et al.
Publicado: ( 201)

Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant
por: JANG, BO-YUN, et al.
Publicado: (2015)

A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates
por: Huang, Edmond Y., et al.
Publicado: (2018)

Encapsulated cargo internalized by fusogenic liposomes partially overlaps the endoplasmic reticulum
por: Mustata, Roxana C, et al.
Publicado: (2009)

Perception of Organic Food Consumption in Romania
por: Petrescu, Anca Gabriela, et al.
Publicado: (2017)

Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer
por: Scott, Emma, et al.
Publicado: (2022)

Publisher Correction: Functional expression of the transient receptor potential ankyrin type 1 channel in pancreatic adenocarcinoma cells
por: Cojocaru, Florentina, et al.
Publicado: (2021)

Functional expression of the transient receptor potential ankyrin type 1 channel in pancreatic adenocarcinoma cells
por: Cojocaru, Florentina, et al.
Publicado: (2021)

CT vs. MRCP in choledocholithiasis jaundice
por: Petrescu, I, et al.
Publicado: (2015)

Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila
por: Pathak, Himani, et al.
Publicado: (2021)

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production
por: Nowakowska-Gołacka, Jowita, et al.
Publicado: (2021)

Numerical simulation and parameter optimization of earth auger in hilly area using EDEM software
por: Wang, Guofu, et al.
Publicado: (2022)

EDEM2 and OS-9 Are Required for ER-Associated Degradation of Non-Glycosylated Sonic Hedgehog
por: Tang, Hsiang-Yun, et al.
Publicado: (2014)

EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression
por: Xu, Yu-Xin, et al.
Publicado: (2020)

Portal Vein and Mesenteric Artery Thrombosis Following the Administration of an Ad26.COV2-S Vaccine—First Case from Romania: A Case Report
por: Savulescu, Florin, et al.
Publicado: (2022)

Balthazar Score and Neutrophil-Lymphocytes Ratio in Acute Pancreatitis
por: PETRESCU, GS, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_po791h81h7v269onec6fqil83m