Cargando…

A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity

Parkinson’s Disease (PD) is the second most common neurodegenerative disease world-wide. Mutations in the multidomain protein Leucine Rich Repeat Kinase 2 (LRRK2) are the most frequent cause of hereditary PD. Furthermore, recent data suggest that independent of mutations, increased kinase activity o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosenbusch, Katharina E., Oun, Asmaa, Sanislav, Oana, Lay, Sui T., Keizer-Gunnink, Ineke, Annesley, Sarah J., Fisher, Paul R., Dolga, Amalia M., Kortholt, Arjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455996/ https://www.ncbi.nlm.nih.gov/pubmed/34568343 http://dx.doi.org/10.3389/fcell.2021.734554

Ejemplares similares

The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton
por: Kicka, Sebastian, et al.
Publicado: (2011)

Roco Proteins: GTPases with a Baroque Structure and Mechanism
por: Wauters, Lina, et al.
Publicado: (2019)

Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages
por: Oun, Asmaa, et al.
Publicado: (2023)

The tale of proteolysis targeting chimeras (PROTACs) for Leucine‐Rich Repeat Kinase 2 (LRRK2)
por: Konstantinidou, Markella, et al.
Publicado: (2020)

Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease
por: Rosenbusch, Katharina E., et al.
Publicado: (2016)

Roco Proteins and the Parkinson’s Disease-Associated LRRK2
por: Liao, Jingling, et al.
Publicado: (2018)

Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling
por: Keizer-Gunnink, Ineke, et al.
Publicado: (2007)

Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis
por: van Haastert, Peter J.M., et al.
Publicado: (2007)

Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement
por: van Haastert, Peter J. M., et al.
Publicado: (2017)

Rap1-dependent pathways coordinate cytokinesis in Dictyostelium
por: Plak, Katarzyna, et al.
Publicado: (2014)

Cytopathological Outcomes of Knocking down Expression of Mitochondrial Complex II Subunits in Dictyostelium discoideum
por: Lay, Sui, et al.
Publicado: (2022)

LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson’s disease: a review
por: Chen, Meng-Ling, et al.
Publicado: (2018)

LRRK2 Structure-Based Activation Mechanism and Pathogenesis
por: Zhang, Xiaojuan, et al.
Publicado: (2023)

LRRK2 Targeting Strategies as Potential Treatment of Parkinson’s Disease
por: Wojewska, Dominika Natalia, et al.
Publicado: (2021)

A Receptor-associated Protein/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation
por: Kortholt, Arjan, et al.
Publicado: (2010)

Allosteric inhibition of LRRK2, where are we now
por: Soliman, Ahmed, et al.
Publicado: (2020)

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation
por: Gilsbach, Bernd K., et al.
Publicado: (2014)

Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis
por: van Haastert, Peter J. M., et al.
Publicado: (2021)

Editorial: LRRK2—Fifteen Years From Cloning to the Clinic
por: Rideout, Hardy, et al.
Publicado: (2022)

Mitochondrial HTRA2 Plays a Positive, Protective Role in Dictyostelium discoideum but Is Cytotoxic When Overexpressed
por: Chen, Suwei, et al.
Publicado: (2018)

Membrane Targeting of C2GAP1 Enables Dictyostelium discoideum to Sense Chemoattractant Gradient at a Higher Concentration Range
por: Xu, Xuehua, et al.
Publicado: (2021)

Interactions and Cytotoxicity of Human Neurodegeneration- Associated Proteins Tau and α-Synuclein in the Simple Model Dictyostelium discoideum
por: Mroczek, Katelyn, et al.
Publicado: (2021)

Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum
por: Bodinier, Romain, et al.
Publicado: (2021)

miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease
por: Oliveira, Sara R., et al.
Publicado: (2021)

Combined FCS and PCH Analysis to Quantify Protein Dimerization in Living Cells
por: Nederveen-Schippers, Laura M., et al.
Publicado: (2021)

Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2
por: Singh, Ranjan K., et al.
Publicado: (2022)

GTP binding controls complex formation by the human ROCO protein MASL1
por: Dihanich, Sybille, et al.
Publicado: (2014)

Cell-Based Blood Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
por: Missailidis, Daniel, et al.
Publicado: (2020)

Dysregulated Gene Expression in Lymphoblasts from Parkinson’s Disease
por: Annesley, Sarah Jane, et al.
Publicado: (2022)

Conformational heterogeneity of the Roc domains in C. tepidum Roc–COR and implications for human LRRK2 Parkinson mutations
por: Rudi, Katharina, et al.
Publicado: (2015)

Drosophila Adducin facilitates phase separation and function of a conserved spindle orientation complex
por: Parra, Amalia S., et al.
Publicado: (2023)

A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells
por: Skoge, Monica, et al.
Publicado: (2016)

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins
por: Tomkins, James E., et al.
Publicado: (2018)

Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction
por: Sabogal-Guáqueta, Angélica María, et al.
Publicado: (2023)

Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts
por: Missailidis, Daniel, et al.
Publicado: (2021)

The Parkinson's disease-associated protein DJ-1 plays a positive nonmitochondrial role in endocytosis in Dictyostelium cells
por: Chen, Suwei, et al.
Publicado: (2017)

Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in Dictyostelium discoideum
por: Fernando, Sanjanie, et al.
Publicado: (2020)

Homer3 regulates the establishment of neutrophil polarity
por: Wu, Julie, et al.
Publicado: (2015)

An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients
por: Missailidis, Daniel, et al.
Publicado: (2020)

The emerging role of LRRK2 in tauopathies
por: Herbst, Susanne, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3g7via5gp5sc31j2u29pmajhiv