Cargando…
Common Threads: Aphidicolin-Inducible and Folate-Sensitive Fragile Sites in the Human Genome
The human genome has many chromosomal regions that are fragile, demonstrating chromatin breaks, gaps, or constrictions on exposure to replication stress. Common fragile sites (CFSs) are found widely distributed in the population, with the largest subset of these sites being induced by aphidicolin (A...
Autores principales: | Lokanga, Rachel Adihe, Kumari, Daman, Usdin, Karen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456018/ https://www.ncbi.nlm.nih.gov/pubmed/34567068 http://dx.doi.org/10.3389/fgene.2021.708860 |
Ejemplares similares
-
Repeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disorders
por: Usdin, Karen, et al.
Publicado: (2014) -
Heterozygosity for a Hypomorphic Polβ Mutation Reduces the Expansion Frequency in a Mouse Model of the Fragile X-Related Disorders
por: Lokanga, Rachel Adihe, et al.
Publicado: (2015) -
Repeat-mediated epigenetic dysregulation of the FMR1 gene in the fragile X-related disorders
por: Usdin, Karen, et al.
Publicado: (2015) -
SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
por: Biacsi, Rea, et al.
Publicado: (2008) -
Pharmacological Reactivation of the Silenced FMR1 Gene as a Targeted Therapeutic Approach for Fragile X Syndrome
por: Kumari, Daman, et al.
Publicado: (2019)