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Prediction and identification of synergistic compound combinations against pancreatic cancer cells

Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations based on transcriptomic profiles from both the disease and compound side,...

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Detalles Bibliográficos
Autores principales: KalantarMotamedi, Yasaman, Choi, Ran Joo, Koh, Siang-Boon, Bramhall, Jo L., Fan, Tai-Ping, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456050/
https://www.ncbi.nlm.nih.gov/pubmed/34585118
http://dx.doi.org/10.1016/j.isci.2021.103080