Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action

Cryptophycin-52 (Cp-52) is potentially the most potent anticancer drug known, with IC(50) values in the low picomolar range, but its binding site on tubulin and mechanism of action are unknown. Here, we have determined the binding site of Cp-52, and its parent compound, cryptophycin-1, on HeLa tubul...

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Detalles Bibliográficos
Autores principales: Eren, Elif, Watts, Norman R., Sackett, Dan L., Wingfield, Paul T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456064/
https://www.ncbi.nlm.nih.gov/pubmed/34461087
http://dx.doi.org/10.1016/j.jbc.2021.101138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456064/
https://www.ncbi.nlm.nih.gov/pubmed/34461087
http://dx.doi.org/10.1016/j.jbc.2021.101138

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