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Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action
Cryptophycin-52 (Cp-52) is potentially the most potent anticancer drug known, with IC(50) values in the low picomolar range, but its binding site on tubulin and mechanism of action are unknown. Here, we have determined the binding site of Cp-52, and its parent compound, cryptophycin-1, on HeLa tubul...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456064/ https://www.ncbi.nlm.nih.gov/pubmed/34461087 http://dx.doi.org/10.1016/j.jbc.2021.101138 |