Crowding affects structural dynamics and contributes to membrane association of the NS3/4A complex

Using molecular dynamics simulations, we describe how crowded environments affect the internal dynamics and diffusion of the hepatitis C virus proteases NS3/4A. This protease plays a key role in viral replication and is successfully used as a target for antiviral treatment. The NS3 enzyme requires a...

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Detalles Bibliográficos
Autores principales: Ostrowska, Natalia, Feig, Michael, Trylska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456185/
https://www.ncbi.nlm.nih.gov/pubmed/34270995
http://dx.doi.org/10.1016/j.bpj.2021.07.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456185/
https://www.ncbi.nlm.nih.gov/pubmed/34270995
http://dx.doi.org/10.1016/j.bpj.2021.07.008

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