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Crowding affects structural dynamics and contributes to membrane association of the NS3/4A complex
Using molecular dynamics simulations, we describe how crowded environments affect the internal dynamics and diffusion of the hepatitis C virus proteases NS3/4A. This protease plays a key role in viral replication and is successfully used as a target for antiviral treatment. The NS3 enzyme requires a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456185/ https://www.ncbi.nlm.nih.gov/pubmed/34270995 http://dx.doi.org/10.1016/j.bpj.2021.07.008 |