Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

Targeting protein – protein interactions (PPIs) has emerged as an important area of discovery for anticancer therapeutic development. In the case of phospho-dependent PPIs, such as the polo-like kinase 1 (Plk1) polo-box domain (PBD), a phosphorylated protein residue can provide high-affinity recogni...

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Detalles Bibliográficos
Autores principales: Hymel, David, Tsuji, Kohei, Grant, Robert A., Chingle, Ramesh M., Kunciw, Dominique L., Yaffe, Michael B., Burke, Terrence R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456285/
https://www.ncbi.nlm.nih.gov/pubmed/34346472
http://dx.doi.org/10.1039/d1ob01120k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456285/
https://www.ncbi.nlm.nih.gov/pubmed/34346472
http://dx.doi.org/10.1039/d1ob01120k

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