ATR Inhibition Induces CDK1–SPOP Signaling and Enhances Anti–PD-L1 Cytotoxicity in Prostate Cancer

PURPOSE: Despite significant benefit for other cancer subtypes, immune checkpoint blockade (ICB) therapy has not yet been shown to significantly improve outcomes for men with castration-resistant prostate cancer (CRPC). Prior data have shown that DNA damage response (DDR) deficiency, via genetic alt...

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Detalles Bibliográficos
Autores principales: Tang, Zhe, Pilié, Patrick G., Geng, Chuandong, Manyam, Ganiraju C., Yang, Guang, Park, Sanghee, Wang, Daoqi, Peng, Shan, Wu, Cheng, Peng, Guang, Yap, Timothy A., Corn, Paul G., Broom, Bradley M., Thompson, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456453/
https://www.ncbi.nlm.nih.gov/pubmed/34168048
http://dx.doi.org/10.1158/1078-0432.CCR-21-1010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456453/
https://www.ncbi.nlm.nih.gov/pubmed/34168048
http://dx.doi.org/10.1158/1078-0432.CCR-21-1010

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