NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis

BACKGROUND: Notch signaling drives many aspects of neoplastic phenotype. Here, we report that the Integrator complex (INT) is a new component of the Notch transcriptional supercomplex. Together with Notch Activation Complex Kinase (NACK), INT activates Notch1 target genes by driving RNA polymerase I...

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Detalles Bibliográficos
Autores principales: Shersher, Elena, Lahiry, Mohini, Alvarez-Trotta, Annamil, Diluvio, Giulia, Robbins, David J., Shiekhattar, Ramin, Capobianco, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456597/
https://www.ncbi.nlm.nih.gov/pubmed/34551776
http://dx.doi.org/10.1186/s12964-021-00776-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456597/
https://www.ncbi.nlm.nih.gov/pubmed/34551776
http://dx.doi.org/10.1186/s12964-021-00776-1

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