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NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis
BACKGROUND: Notch signaling drives many aspects of neoplastic phenotype. Here, we report that the Integrator complex (INT) is a new component of the Notch transcriptional supercomplex. Together with Notch Activation Complex Kinase (NACK), INT activates Notch1 target genes by driving RNA polymerase I...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456597/ https://www.ncbi.nlm.nih.gov/pubmed/34551776 http://dx.doi.org/10.1186/s12964-021-00776-1 |