Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer

BACKGROUND: Chemoresistance is the major cause of chemotherapy failure in patients with colorectal cancer (CRC). Protein tyrosine kinase 6 (PTK6) is aberrantly overexpressed in clinical CRC tissues undergoing chemotherapy. We studied if PTK6 contributed to the chemoresistance of CRC in human and mic...

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Detalles Bibliográficos
Autores principales: Liu, Chaoqun, Pan, Zhihua, Chen, Qian, Chen, Zetao, Liu, Weiwei, Wu, Ling, Jiang, Muhong, Lin, Wandie, Zhang, Yujie, Lin, Weihao, Zhou, Rui, Zhao, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456648/
https://www.ncbi.nlm.nih.gov/pubmed/34551797
http://dx.doi.org/10.1186/s13046-021-02059-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456648/
https://www.ncbi.nlm.nih.gov/pubmed/34551797
http://dx.doi.org/10.1186/s13046-021-02059-6

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