The Mechanism of Dehydrating Bimodules in trans‐Acyltransferase Polyketide Biosynthesis: A Showcase Study on Hepatoprotective Hangtaimycin

A bioassay‐guided fractionation led to the isolation of hangtaimycin (HTM) from Streptomyces spectabilis CCTCC M2017417 and the discovery of its hepatoprotective properties. Structure elucidation by NMR suggested the need for a structural revision. A putative HTM degradation product was also isolate...

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Detalles Bibliográficos
Autores principales: Luo, Minghe, Xu, Houchao, Dong, Yulu, Shen, Kun, Lu, Junlei, Yin, Zhiyong, Qi, Miaomiao, Sun, Guo, Tang, Lingjie, Xiang, Jin, Deng, Zixin, Dickschat, Jeroen S., Sun, Yuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456789/
https://www.ncbi.nlm.nih.gov/pubmed/34219345
http://dx.doi.org/10.1002/anie.202106250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456789/
https://www.ncbi.nlm.nih.gov/pubmed/34219345
http://dx.doi.org/10.1002/anie.202106250

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