Nickel‐Catalyzed Thiolation of Aryl Nitriles

A nickel‐catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2‐bis(dicyclohexylphosphino)ethane) as well as the base KO(t)Bu (potassium tert‐butoxide) are essential to achieve this transformation. This scalable and practical process...

Descripción completa

Detalles Bibliográficos
Autores principales: Delcaillau, Tristan, Morandi, Bill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456793/
https://www.ncbi.nlm.nih.gov/pubmed/34114686
http://dx.doi.org/10.1002/chem.202101273
Descripción
Sumario:A nickel‐catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2‐bis(dicyclohexylphosphino)ethane) as well as the base KO(t)Bu (potassium tert‐butoxide) are essential to achieve this transformation. This scalable and practical process involves both a C−C bond activation and a C−S bond formation. Furthermore, this reaction shows a high functional‐group tolerance and enables the late‐stage functionalization of important molecules.

Ejemplares similares