An Alkyne‐Metathesis‐Based Approach to the Synthesis of the Anti‐Malarial Macrodiolide Samroiyotmycin A

We report the first total synthesis of samroiyotmycin A (1), a C(2)‐symmetric 20‐membered anti‐malarial macrodiolide isolated from Streptomyces sp. The convergent synthetic strategy orchestrates bisalkyne fragment‐assembly using an unprecedented Schöllkopf‐type condensation on a substituted β‐lacton...

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Detalles Bibliográficos
Autores principales: Yiannakas, Ektoras, Grimes, Mark I., Whitelegge, James T., Fürstner, Alois, Hulme, Alison N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456858/
https://www.ncbi.nlm.nih.gov/pubmed/34076945
http://dx.doi.org/10.1002/anie.202105732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456858/
https://www.ncbi.nlm.nih.gov/pubmed/34076945
http://dx.doi.org/10.1002/anie.202105732

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