Selective (13)C‐Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins

A combined chemo‐enzymatic synthesis/NMR‐based methodology is presented to identify, in unambiguous manner, the distinctive binding epitope within repeating sugar oligomers when binding to protein receptors. The concept is based on the incorporation of (13)C‐labels at specific monosaccharide units,...

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Detalles Bibliográficos
Autores principales: Moure, María J., Gimeno, Ana, Delgado, Sandra, Diercks, Tammo, Boons, Geert‐Jan, Jiménez‐Barbero, Jesús, Ardá, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456918/
https://www.ncbi.nlm.nih.gov/pubmed/34128568
http://dx.doi.org/10.1002/anie.202106056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456918/
https://www.ncbi.nlm.nih.gov/pubmed/34128568
http://dx.doi.org/10.1002/anie.202106056

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