Rationalizing the Unprecedented Stereochemistry of an Enzymatic Nitrile Synthesis through a Combined Computational and Experimental Approach

In this contribution, the unique and unprecedented stereochemical phenomenon of an aldoxime dehydratase‐catalyzed enantioselective dehydration of racemic E‐ and Z‐aldoximes with selective formation of both enantiomeric forms of a chiral nitrile is rationalized by means of molecular modelling, compri...

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Detalles Bibliográficos
Autores principales: Yavuzer, Hilmi, Asano, Yasuhisa, Gröger, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456930/
https://www.ncbi.nlm.nih.gov/pubmed/33886145
http://dx.doi.org/10.1002/anie.202017234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456930/
https://www.ncbi.nlm.nih.gov/pubmed/33886145
http://dx.doi.org/10.1002/anie.202017234

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