Structure‐Guided Design of G‐Protein‐Coupled Receptor Polypharmacology

Many diseases are polygenic and can only be treated efficiently with drugs that modulate multiple targets. However, rational design of compounds with multi‐target profiles is rarely pursued because it is considered too difficult, in particular if the drug must enter the central nervous system. Here,...

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Detalles Bibliográficos
Autores principales: Kampen, Stefanie, Duy Vo, Duc, Zhang, Xiaoqun, Panel, Nicolas, Yang, Yunting, Jaiteh, Mariama, Matricon, Pierre, Svenningsson, Per, Brea, Jose, Loza, Maria Isabel, Kihlberg, Jan, Carlsson, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456950/
https://www.ncbi.nlm.nih.gov/pubmed/33904641
http://dx.doi.org/10.1002/anie.202101478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456950/
https://www.ncbi.nlm.nih.gov/pubmed/33904641
http://dx.doi.org/10.1002/anie.202101478

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