Selective Bacterial Targeting and Infection‐Triggered Release of Antibiotic Colistin Conjugates

In order to render potent, but toxic antibiotics more selective, we have explored a novel conjugation strategy that includes drug accumulation followed by infection‐triggered release of the drug. Bacterial targeting was achieved using a modified fragment of the human antimicrobial peptide ubiquicidi...

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Detalles Bibliográficos
Autores principales: Tegge, Werner, Guerra, Giulia, Höltke, Alexander, Schiller, Lauritz, Beutling, Ulrike, Harmrolfs, Kirsten, Gröbe, Lothar, Wullenkord, Hannah, Xu, Chunfa, Weich, Herbert, Brönstrup, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456958/
https://www.ncbi.nlm.nih.gov/pubmed/34097810
http://dx.doi.org/10.1002/anie.202104921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456958/
https://www.ncbi.nlm.nih.gov/pubmed/34097810
http://dx.doi.org/10.1002/anie.202104921

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