Oligonucleotide Phosphorothioates Enter Cells by Thiol‐Mediated Uptake

Oligonucleotide phosphorothioates (OPS) are DNA or RNA mimics where one phosphate oxygen is replaced by a sulfur atom. They have been shown to enter mammalian cells much more efficiently than non‐modified DNA. Thus, solving one of the key challenges with oligonucleotide technology, OPS became very u...

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Detalles Bibliográficos
Autores principales: Laurent, Quentin, Martinent, Rémi, Moreau, Dimitri, Winssinger, Nicolas, Sakai, Naomi, Matile, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456962/
https://www.ncbi.nlm.nih.gov/pubmed/34173696
http://dx.doi.org/10.1002/anie.202107327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456962/
https://www.ncbi.nlm.nih.gov/pubmed/34173696
http://dx.doi.org/10.1002/anie.202107327

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