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An uncommon [K(+)(Mg(2+))(2)] metal ion triad imparts stability and selectivity to the Guanidine-I riboswitch

The widespread ykkC-I riboswitch class exemplifies divergent riboswitch evolution. To analyze how natural selection has diversified its versatile RNA fold, we determined the X-ray crystal structure of the Burkholderia sp. TJI49 ykkC-I subtype-1 (Guanidine-I) riboswitch aptamer domain. Differing from...

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Detalles Bibliográficos
Autores principales: Trachman, Robert J., Ferré-D'Amaré, Adrian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457001/
https://www.ncbi.nlm.nih.gov/pubmed/34257148
http://dx.doi.org/10.1261/rna.078824.121