Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identify disease-relevant transcripts containing G-rich motifs

XRN1 is a highly conserved exoribonuclease which degrades uncapped RNAs in a 5′–3′ direction. Degradation of RNAs by XRN1 is important in many cellular and developmental processes and is relevant to human disease. Studies in D. melanogaster demonstrate that XRN1 can target specific RNAs, which have...

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Detalles Bibliográficos
Autores principales: Pashler, Amy L., Towler, Benjamin P., Jones, Christopher I., Haime, Hope J., Burgess, Tom, Newbury, Sarah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457002/
https://www.ncbi.nlm.nih.gov/pubmed/34266995
http://dx.doi.org/10.1261/rna.078872.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457002/
https://www.ncbi.nlm.nih.gov/pubmed/34266995
http://dx.doi.org/10.1261/rna.078872.121

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