Blocking glutamate mGlu(5) receptors with the negative allosteric modulator CTEP improves disease course in SOD1(G93A) mouse model of amyotrophic lateral sclerosis

BACKGROUND AND PURPOSE: The pathogenesis of amyotrophic lateral sclerosis (ALS) is not fully clarified, although excessive glutamate (Glu) transmission and the downstream cytotoxic cascades are major mechanisms for motor neuron death. Two metabotropic glutamate receptors (mGlu(1) and mGlu(5)) are ov...

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Detalles Bibliográficos
Autores principales: Milanese, Marco, Bonifacino, Tiziana, Torazza, Carola, Provenzano, Francesca, Kumar, Mandeep, Ravera, Silvia, Zerbo, Arianna Roberta, Frumento, Giulia, Balbi, Matilde, Nguyen, T. P. Nhung, Bertola, Nadia, Ferrando, Sara, Viale, Maurizio, Profumo, Aldo, Bonanno, Giambattista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457068/
https://www.ncbi.nlm.nih.gov/pubmed/33931856
http://dx.doi.org/10.1111/bph.15515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457068/
https://www.ncbi.nlm.nih.gov/pubmed/33931856
http://dx.doi.org/10.1111/bph.15515

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