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Blocking glutamate mGlu(5) receptors with the negative allosteric modulator CTEP improves disease course in SOD1(G93A) mouse model of amyotrophic lateral sclerosis
BACKGROUND AND PURPOSE: The pathogenesis of amyotrophic lateral sclerosis (ALS) is not fully clarified, although excessive glutamate (Glu) transmission and the downstream cytotoxic cascades are major mechanisms for motor neuron death. Two metabotropic glutamate receptors (mGlu(1) and mGlu(5)) are ov...
Autores principales: | Milanese, Marco, Bonifacino, Tiziana, Torazza, Carola, Provenzano, Francesca, Kumar, Mandeep, Ravera, Silvia, Zerbo, Arianna Roberta, Frumento, Giulia, Balbi, Matilde, Nguyen, T. P. Nhung, Bertola, Nadia, Ferrando, Sara, Viale, Maurizio, Profumo, Aldo, Bonanno, Giambattista |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457068/ https://www.ncbi.nlm.nih.gov/pubmed/33931856 http://dx.doi.org/10.1111/bph.15515 |
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