Repeated exposure to JWH‐018 induces adaptive changes in the mesolimbic and mesocortical dopaminergic pathways, glial cells alterations, and behavioural correlates

BACKGROUND AND PURPOSE: Spice/K2 herbal mixtures, containing synthetic cannabinoids such as JWH‐018, have been marketed as marijuana surrogates since 2004. JWH‐018 has cannabinoid CB(1) receptor‐dependent reinforcing properties and acutely increases dopaminergic transmission selectively in the NAc s...

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Detalles Bibliográficos
Autores principales: Pintori, Nicholas, Castelli, Maria Paola, Miliano, Cristina, Simola, Nicola, Fadda, Paola, Fattore, Liana, Scherma, Maria, Ennas, Maria Grazia, Mostallino, Rafaela, Flore, Giovanna, De Felice, Marta, Sagheddu, Claudia, Pistis, Marco, Di Chiara, Gaetano, De Luca, Maria Antonietta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457172/
https://www.ncbi.nlm.nih.gov/pubmed/33837969
http://dx.doi.org/10.1111/bph.15494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457172/
https://www.ncbi.nlm.nih.gov/pubmed/33837969
http://dx.doi.org/10.1111/bph.15494

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