Understanding and Engineering the Stereoselectivity of Humulene Synthase

The non‐canonical terpene cyclase AsR6 is responsible for the formation of 2E,6E,9E‐humulene during the biosynthesis of the tropolone sesquiterpenoid (TS) xenovulene A. The structures of unliganded AsR6 and of AsR6 in complex with an in crystallo cyclized reaction product and thiolodiphosphate revea...

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Detalles Bibliográficos
Autores principales: Schotte, Carsten, Lukat, Peer, Deuschmann, Adrian, Blankenfeldt, Wulf, Cox, Russell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457177/
https://www.ncbi.nlm.nih.gov/pubmed/34180566
http://dx.doi.org/10.1002/anie.202106718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457177/
https://www.ncbi.nlm.nih.gov/pubmed/34180566
http://dx.doi.org/10.1002/anie.202106718

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