NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery

NleB/SseK effectors are arginine-GlcNAc-transferases expressed by enteric bacterial pathogens that modify host cell proteins to disrupt signaling pathways. While the conserved Citrobacter rodentium NleB and E. coli NleB1 proteins display a broad selectivity towards host proteins, Salmonella enterica...

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Detalles Bibliográficos
Autores principales: García-García, Ana, Hicks, Thomas, El Qaidi, Samir, Zhu, Congrui, Hardwidge, Philip R., Angulo, Jesús, Hurtado-Guerrero, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457375/
https://www.ncbi.nlm.nih.gov/pubmed/34667584
http://dx.doi.org/10.1039/d1sc04065k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457375/
https://www.ncbi.nlm.nih.gov/pubmed/34667584
http://dx.doi.org/10.1039/d1sc04065k

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