Catalytic enantioselective synthesis of 1,4-dihydropyridines via the addition of C(1)-ammonium enolates to pyridinium salts

The regio- and stereoselective addition of C(1)-ammonium enolates – generated in situ from aryl esters and the isothiourea catalyst (R)-BTM – to pyridinium salts bearing an electron withdrawing substituent in the 3-position allows the synthesis of a range of enantioenriched 1,4-dihydropyridines. Thi...

Descripción completa

Detalles Bibliográficos
Autores principales: McLaughlin, Calum, Bitai, Jacqueline, Barber, Lydia J., Slawin, Alexandra M. Z., Smith, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457386/
https://www.ncbi.nlm.nih.gov/pubmed/34667566
http://dx.doi.org/10.1039/d1sc03860e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457386/
https://www.ncbi.nlm.nih.gov/pubmed/34667566
http://dx.doi.org/10.1039/d1sc03860e

Ejemplares similares