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Catalytic enantioselective synthesis of 1,4-dihydropyridines via the addition of C(1)-ammonium enolates to pyridinium salts

The regio- and stereoselective addition of C(1)-ammonium enolates – generated in situ from aryl esters and the isothiourea catalyst (R)-BTM – to pyridinium salts bearing an electron withdrawing substituent in the 3-position allows the synthesis of a range of enantioenriched 1,4-dihydropyridines. Thi...

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Detalles Bibliográficos
Autores principales:	McLaughlin, Calum, Bitai, Jacqueline, Barber, Lydia J., Slawin, Alexandra M. Z., Smith, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457386/ https://www.ncbi.nlm.nih.gov/pubmed/34667566 http://dx.doi.org/10.1039/d1sc03860e

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