RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation

As a systemic disease, osteoporosis (OP) results in bone density loss and fracture risk, particularly in the hip and vertebrae. However, the underlying molecular mechanisms of OP development have not been fully illustrated. N6-Methyladenosine (m6A) is the most abundant modification of mRNAs, which i...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Fu, Qiang, Yang, Jian, Liu, Jin-Long, Hou, Shu-Ming, Huang, Xing, Cao, Jia-Shi, Liu, Tie-Long, Wang, Kun-Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457567/
https://www.ncbi.nlm.nih.gov/pubmed/34496349
http://dx.doi.org/10.18632/aging.203377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457567/
https://www.ncbi.nlm.nih.gov/pubmed/34496349
http://dx.doi.org/10.18632/aging.203377

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