Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells

Betulinic acid (BA), a pentacyclic triterpenoid isolated from tree bark, exhibits antitumor effects against solid malignancies and triggers autophagy and/or apoptosis in human cancer cells. Nonetheless, the relationship between autophagy and apoptosis and the potential modulatory actions of BA on au...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, He, Ning, Zhou, Xuejian, Wang, Feifan, Cai, Hairong, Huang, Shih Han, Chen, Xianwu, Hu, Zhenghui, Jin, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457576/
https://www.ncbi.nlm.nih.gov/pubmed/34510030
http://dx.doi.org/10.18632/aging.203441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457576/
https://www.ncbi.nlm.nih.gov/pubmed/34510030
http://dx.doi.org/10.18632/aging.203441

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