Cargando…

Astrocyte-derived exosomes protect hippocampal neurons after traumatic brain injury by suppressing mitochondrial oxidative stress and apoptosis

In this study, we investigated the mechanisms through which astrocyte-derived exosomes (AS-Exos) alleviate traumatic brain injury (TBI)-induced neuronal defects in TBI model rats and mice. Treatment with AS-Exos alleviated neurobehavioral deficits, cognitive impairment, and brain edema in TBI rats....

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wenqian, Hong, Jun, Zhang, Hanwen, Zheng, Wencheng, Yang, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457605/ https://www.ncbi.nlm.nih.gov/pubmed/34516406 http://dx.doi.org/10.18632/aging.203508

Ejemplares similares

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes
por: Jiang, Dongdong, et al.
Publicado: (2020)

Mesenchymal Stem Cell-Conditioned Medium Protects Hippocampal Neurons From Radiation Damage by Suppressing Oxidative Stress and Apoptosis
por: Huang, Yue, et al.
Publicado: (2021)

Astrocytes Protect Neurons in the Hippocampal CA3 Against Ischemia by Suppressing the Intracellular Ca(2+) Overload
por: Sun, Chuanqi, et al.
Publicado: (2018)

Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons
por: Zárate, Sandra Cristina, et al.
Publicado: (2019)

Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection
por: Mengying, Zhang, et al.
Publicado: (2017)

Troxerutin protects hippocampal neurons against amyloid beta-induced oxidative stress and apoptosis
por: Farajdokht, Fereshteh, et al.
Publicado: (2017)

Exosomes From Astrocyte Processes: Signaling to Neurons
por: Venturini, Arianna, et al.
Publicado: (2019)

High glucose exacerbates neuroinflammation and apoptosis at the intermediate stage after post-traumatic brain injury
por: Zhang, Wenqian, et al.
Publicado: (2021)

Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity
por: Winston, Charisse N., et al.
Publicado: (2019)

MiRNAs in Astrocyte-Derived Exosomes as Possible Mediators of Neuronal Plasticity
por: Lafourcade, Carlos, et al.
Publicado: (2016)

Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
por: Yu, Tzong-Shiue, et al.
Publicado: (2021)

Astrocyte-Specific Overexpression of Insulin-Like Growth Factor-1 Protects Hippocampal Neurons and Reduces Behavioral Deficits following Traumatic Brain Injury in Mice
por: Madathil, Sindhu K., et al.
Publicado: (2013)

Photo-Induced Oxidative Stress Impairs Mitochondrial Metabolism in Neurons and Astrocytes
por: Berezhnaya, Elena, et al.
Publicado: (2017)

Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria‐mediated apoptosis in cultured hippocampal neurons
por: Qu, Mingyue, et al.
Publicado: (2020)

Engulfing Astrocytes Protect Neurons from Contact-Induced Apoptosis following Injury
por: Lööv, Camilla, et al.
Publicado: (2012)

Genistein suppresses the mitochondrial apoptotic pathway in hippocampal neurons in rats with Alzheimer's disease
por: Wang, Yan, et al.
Publicado: (2016)

Icariin Protects Hippocampal Neurons From Endoplasmic Reticulum Stress and NF-κB Mediated Apoptosis in Fetal Rat Hippocampal Neurons and Asthma Rats
por: Liu, Jiaqi, et al.
Publicado: (2020)

Isoflurane-induced neuronal apoptosis in developing hippocampal neurons☆
por: Liu, Hongliang, et al.
Publicado: (2013)

Astrocyte-derived exosome-transported GJA1-20k attenuates traumatic brain injury in rats
por: Feng, Jiugeng, et al.
Publicado: (2023)

Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure
por: Xu, Bin, et al.
Publicado: (2019)

Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons
por: Shen, Yi, et al.
Publicado: (2016)

Epileptiform Neuronal Discharges Impair Astrocyte Syncytial Isopotentiality in Acute Hippocampal Slices
por: Wang, Qi, et al.
Publicado: (2020)

Effects of ethanol-and choline-treated astrocytes on hippocampal neuron neurite outgrowth in vitro
por: Goeke, Calla M, et al.
Publicado: (2021)

Astrocytes in CA1 modulate schema establishment in the hippocampal-cortical neuron network
por: Liu, Shu, et al.
Publicado: (2022)

GABA release by hippocampal astrocytes
por: Le Meur, Karim, et al.
Publicado: (2012)

Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK/MLCK signaling
por: Xu, Yongjie, et al.
Publicado: (2021)

Dopamine Inhibits Mitochondrial Motility in Hippocampal Neurons
por: Chen, Sigeng, et al.
Publicado: (2008)

Fatty Acids Modify the MicroRNA Content of Exosomes Released by Hypothalamic Astrocytes and the Response of POMC Neurons to These Exosomes
por: Collado-Pérez, Roberto, et al.
Publicado: (2021)

Caveolin‐1 suppresses hippocampal neuron apoptosis via the regulation of HIF1α in hypoxia in naked mole‐rats
por: Yang, Wenjing, et al.
Publicado: (2022)

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage
por: Kageyama, Yusuke, et al.
Publicado: (2012)

Sulbactam Protects Hippocampal Neurons Against Oxygen-Glucose Deprivation by Up-Regulating Astrocytic GLT-1 via p38 MAPK Signal Pathway
por: Qi, Jie, et al.
Publicado: (2018)

Macrophage-Derived Exosomes in TLR9(−/−) Mice Ameliorate Sepsis-Induced Mitochondrial Oxidative Stress and Apoptosis in Cardiomyocytes
por: Li, Xiang, et al.
Publicado: (2022)

ClC-3 chloride channel in hippocampal neuronal apoptosis
por: Xu, Lijuan, et al.
Publicado: (2013)

Metformin Alleviated Aβ-Induced Apoptosis via the Suppression of JNK MAPK Signaling Pathway in Cultured Hippocampal Neurons
por: Chen, Bin, et al.
Publicado: (2016)

MicroRNA-132 protects hippocampal neurons against oxygen-glucose deprivation–induced apoptosis
por: Sun, Zu-Zhen, et al.
Publicado: (2017)

Opening of Astrocytic Mitochondrial ATP-Sensitive Potassium Channels Upregulates Electrical Coupling between Hippocampal Astrocytes in Rat Brain Slices
por: Wang, Jiangping, et al.
Publicado: (2013)

Overexpression of phosphoprotein enriched in astrocytes 15 reverses the damage induced by propofol in hippocampal neurons
por: Xian, Feng, et al.
Publicado: (2019)

Hippocampal and Cortical Pyramidal Neurons Swell in Parallel with Astrocytes during Acute Hypoosmolar Stress
por: Murphy, Thomas R., et al.
Publicado: (2017)

Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1
por: McCauley, John P., et al.
Publicado: (2020)

Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity‐dependent regulatory mechanisms
por: Wang, Ye, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mvflkfqhbe65rrfjkbr6n2nluq