Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape

The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively). Missense variants render PAI-1 non-functional through misfoldi...

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Detalles Bibliográficos
Autores principales: Huttinger, Zachary M., Haynes, Laura M., Yee, Andrew, Kretz, Colin A., Holding, Matthew L., Siemieniak, David R., Lawrence, Daniel A., Ginsburg, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458277/
https://www.ncbi.nlm.nih.gov/pubmed/34552126
http://dx.doi.org/10.1038/s41598-021-97871-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458277/
https://www.ncbi.nlm.nih.gov/pubmed/34552126
http://dx.doi.org/10.1038/s41598-021-97871-7

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