Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists

EPI-X4, a 16-mer fragment of albumin, is a specific endogenous antagonist and inverse agonist of the CXC-motif-chemokine receptor 4 (CXCR4) and thus a key regulator of CXCR4 function. Accordingly, activity-optimized synthetic derivatives of EPI-X4 are promising leads for the therapy of CXCR4-linked...

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Detalles Bibliográficos
Autores principales: Sokkar, Pandian, Harms, Mirja, Stürzel, Christina, Gilg, Andrea, Kizilsavas, Gönül, Raasholm, Martina, Preising, Nico, Wagner, Manfred, Kirchhoff, Frank, Ständker, Ludger, Weidinger, Gilbert, Mayer, Benjamin, Münch, Jan, Sanchez-Garcia, Elsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458281/
https://www.ncbi.nlm.nih.gov/pubmed/34552197
http://dx.doi.org/10.1038/s42003-021-02638-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458281/
https://www.ncbi.nlm.nih.gov/pubmed/34552197
http://dx.doi.org/10.1038/s42003-021-02638-5

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