Systems approaches identify the consequences of monosomy in somatic human cells

Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we find that chromosome loss impairs proliferation and genomic stability. Transcriptome and proteome...

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Detalles Bibliográficos
Autores principales: Chunduri, Narendra Kumar, Menges, Paul, Zhang, Xiaoxiao, Wieland, Angela, Gotsmann, Vincent Leon, Mardin, Balca R., Buccitelli, Christopher, Korbel, Jan O., Willmund, Felix, Kschischo, Maik, Raeschle, Markus, Storchova, Zuzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458293/
https://www.ncbi.nlm.nih.gov/pubmed/34552071
http://dx.doi.org/10.1038/s41467-021-25288-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458293/
https://www.ncbi.nlm.nih.gov/pubmed/34552071
http://dx.doi.org/10.1038/s41467-021-25288-x

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