Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions

Genetic sensors with unique combinations of DNA recognition and allosteric response can be created by hybridizing DNA-binding modules (DBMs) and ligand-binding modules (LBMs) from distinct transcriptional repressors. This module swapping approach is limited by incompatibility between DBMs and LBMs f...

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Detalles Bibliográficos
Autores principales: Jiang, Xian-Li, Dimas, Rey P., Chan, Clement T. Y., Morcos, Faruck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458406/
https://www.ncbi.nlm.nih.gov/pubmed/34552074
http://dx.doi.org/10.1038/s41467-021-25851-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458406/
https://www.ncbi.nlm.nih.gov/pubmed/34552074
http://dx.doi.org/10.1038/s41467-021-25851-6

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