Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model

Mucus clearance, a primary innate defense mechanism of airways, is defective in patients with cystic fibrosis (CF) and CF animals. In previous work, the combination of a low dose of the cholinergic agonist, carbachol with forskolin or a β adrenergic agonist, isoproterenol synergistically increased m...

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Detalles Bibliográficos
Autores principales: Joo, Nam Soo, Cho, Hyung-Ju, Shinbashi, Meagan, Choi, Jae Young, Milla, Carlos E., Engelhardt, John F., Wine, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458446/
https://www.ncbi.nlm.nih.gov/pubmed/34552115
http://dx.doi.org/10.1038/s41598-021-98122-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458446/
https://www.ncbi.nlm.nih.gov/pubmed/34552115
http://dx.doi.org/10.1038/s41598-021-98122-5

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